Prevagen Review: Does It Really Work?

prevagen review memory supplement

31st October 2023

A Closer Look at Prevagen And Quincy Bioscience

When it comes to brain and memory supplements, Prevagen, from Quincy Bioscience, is a name that often pops up. Prevagen is composed of just two primary ingredients: Vitamin D (50mcg) and Apoaequorin (10mg). But the real question is, does it actually work? In this review, we'll break down the evidence behind its claims, delve into the specifics of its ingredients and their dosages [1].

But here's a heads up: There are a lot of negative reviews for both the product and its parent company, Quincy Bioscience. We're not ones to shy away from tough topics, so we'll also cover these concerns [2]. And if you're considering alternatives, stick around - we've got insights on those too.

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Overall Results And Recommendation

Prevagen

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  • Disappointing Results: Prevagen's cognitive effects were subdued, with very little improvement experienced in memory and focus during our testing.
  • Missing Key Ingredients: Lacks many clinically-proven nootropic ingredients commonly found in top-tier brain and memory supplements.
  • Unconvincing Evidence: Most studies on apoaequorin originate from its manufacturers, raising validity concerns. Prevagen has also faced legal scrutiny for misleading advertising about its memory-enhancement claims, which were deemed unsubstantiated by regulators.
  • Cost vs. Efficacy: Given its price point, the tangible benefits delivered were disappointing.
  • Alternative Recommendation: NooCube outperformed Prevagen in our tests, delivering noticeable improvements to cognitive performance and memory. It's well-researched, scientifically backed, and our firsthand experience validated its efficacy claims.

NooCube

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Quick Decision Guide - Quantumind vs Leading Nootropic (NooCube)

CRITERIA

Prevagen

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NooCube

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Overall Rating (From Our Experience Using Each Product)

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Main Benefits

Experimental and unproven novel ingredient claimed to support brain function and memory

Comprehensive cognitive improvement spanning brain health, cognitive performance and memory with a multi-ingredient blend

Scientific Backing

Limited and controversial

Strong, with many well-researched ingredients

Formula Complexity

Basic

Comprehensive

Brand Reputation Concerns

FTC legal ruling against Prevagen's manufacturer

Minimal to none

Cost

Premium

Premium

Commitment Time for Results

Months with variable results

Weeks, consistent use recommended

Servings Per Container

30

30

Capsules Per Container

30

90

User Feedback

Mixed, with many users citing minimal or no effects

Predominantly positive

Ingredients' Transparency

Mostly disclosed but with opaque proprietary ingredient (Apoaequorin)

Fully disclosed

Dosage Convenience

1 capsule daily

3 capsules daily

Potential Side Effects

Moderate risk

Low risk

Customer Support & Return Policy

Mixed reviews on customer service; return policy varies

Excellent, 60 day money-back guarantee

Product Availability

Widely available, some regional restrictions

Available through official site only

Additional Benefits

Some claims of improved sleep by some users

Boosts neurotransmitters, enhanced neuroprotection

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What Is Prevagen?

Prevagen is a dietary supplement that has positioned itself prominently within the nootropic market, an industry dedicated to enhancing cognitive function and brain health. The primary claim made by Prevagen is its supposed ability to support healthy brain function and improve memory.

Central to its formulation is an ingredient known as apoaequorin [3], a protein originally sourced from a type of jellyfish. Prevagen’s marketing emphasizes that this protein is not only safe but also particularly adept at supporting brain function. The brand leans heavily on a specific clinical study which suggests that apoaequorin can be beneficial for individuals who are either cognitively normal or show signs of mild cognitive impairment.

Apart from apoaequorin, the supplement also contains Vitamin D, a vitamin known for its multiple health benefits, including its potential role in cognitive health [4].

However, while its marketing material is compelling, Prevagen's scientific foundation has come under scrutiny. Many experts have raised concerns about the lack of peer-reviewed research substantiating the product's claims [5]. This becomes even more pertinent given the brand's history of legal and regulatory challenges, especially concerning their marketing and promotional tactics [6].

Prevagen: Legal Issues

Prevagen came under the legal spotlight after the Federal Trade Commission (FTC) and New York State Attorney General challenged its makers, Quincy Bioscience, over their advertising practices. Specifically, the regulators contended that the company's cognitive health claims, particularly concerning memory enhancement, were unsubstantiated and misleading. Such regulatory actions raise concerns over the credibility of the brand and underscore the importance of evidence-based claims in the supplement industry. Notably, while many supplements make health-related claims, it's essential that these claims are backed by robust scientific research to ensure consumer safety and trust [7-10].

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Prevagen: A Critical Examination of Its Claims and Credibility

Prevagen positions itself as a solution to boost brain function and memory. A unique feature of Prevagen is its inclusion of apoaequorin [11], an ingredient the brand promotes as safe and uniquely suited for enhancing brain activity. Their cornerstone argument revolves around a clinical study suggesting apoaequorin's effectiveness among certain groups, notably those with standard cognitive function or minor impairments [12].

Prevagen dubs itself a 'breakthrough' for the brain and memory, citing improvements specifically in short-term memory capabilities3. One would expect such a supplement to be rooted in extensive, peer-reviewed research, given its bold assertions. However, a deeper dive into the scientific landscape reveals a notable absence of peer-reviewed validation for these claims [13].

Backing Prevagen's ambitious pursuits is Quincy Bioscience, headquartered in Madison, Wisconsin. The company outlines its mission as pioneering innovations centered on cognitive enhancements and tackling challenges such as age-related memory decline [14]. At face value, this sounds commendable. Yet, a look into their history unearths a slew of legal troubles and concerns regarding their marketing strategies [15], casting a shadow on their credibility.

Given this backdrop, it becomes essential for consumers to approach Prevagen's claims with an informed, discerning perspective. While the allure of enhanced cognitive function is tempting, relying solely on brand-propagated evidence, especially from a company with a checkered past, is a precarious position [16].

Prevagen's Claim: "Prevagen is an over-the-counter supplement for healthy brain function and memory improvement".
The Reality: While the nootropic market has many supplements that claim to boost brain function and memory, the efficacy of Prevagen hinges primarily on its unique ingredient, apoaequorin. Comprehensive research validating these broad claims, especially concerning long-term use and its effectiveness across diverse populations, remains scanty [17].

Prevagen's Claim: "Prevagen is formulated with apoaequorin which is safe and uniquely supports brain function as shown in a clinical study of subgroups of individuals who were cognitively normal or mildly impaired".
The Reality: Apoaequorin has indeed been highlighted in certain studies, but many of these lack peer review or are funded by parties with vested interests. Additionally, the specific clinical study cited has been critiqued for its methodology and transparency [18]. Safety is another concern; while initial studies suggest it's generally safe for consumption, more rigorous, independent, long-term studies are needed to confirm this [19].

Prevagen's Claim: "A breakthrough which helps your brain and helps memory. Shown to improve short-term memory".
The Reality: The term "breakthrough" implies a significant scientific discovery. As of now, the evidence supporting Prevagen's effect on short-term memory is not robust enough to warrant this label [20]. Preliminary findings do indicate potential benefits, but these are not universally accepted in the scientific community.

Prevagen's Claim: "Quincy Bioscience, makers of Prevagen, is focused on the discovery and development of novel technologies to support cognitive function and other normal health challenges such as mild memory loss associated with aging."
The Reality: While Quincy Bioscience's dedication to cognitive health is evident, it's worth noting that they have faced legal challenges concerning their marketing practices [21], which might raise eyebrows regarding their overall credibility.

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Does Prevagen Really Work?

Our Experience With Prevagen: A Reality Check

Upon embarking on our trial with Prevagen, we were naturally intrigued by its confident promises: a panacea for memory improvement and healthy brain function. Such claims are, of course, enticing, especially given the buzz around apoaequorin [22] and its potential role in cognitive health. We approached our experiment with the intention of rigorous, unbiased evaluation.

In the initial phase of our experience, we keenly observed for any noticeable surge in cognitive capabilities. Vitamin D, an essential nutrient, has been associated with several physiological processes, including mood regulation and cognitive function [23]. With 50mcg of Vitamin D in Prevagen's formulation, we anticipated some level of mood stabilization and cognitive clarity. However, the effect, if any, was subtle.

The more intriguing part of the product's formula, apoaequorin, is emphasized by Prevagen as its revolutionary ingredient, with the brand claiming it provides support for brain function [24]. Over the weeks, while there were moments of perceived clarity, the overarching sensation was one of muted impact. Specifically, the short-term memory improvements, a pivotal promise made by the brand, didn't manifest in any remarkable way during our trial [25].

Contrasting our real-world experience with Prevagen’s bold claims, the delta was evident. The touted "breakthrough" for the brain and memory didn't align with our observations, a sentiment echoed in various academic circles that challenge the product's robustness in delivering its promises [26,27].

While Quincy Bioscience’s mission to address cognitive challenges is commendable, our direct encounter with their flagship product was somewhat underwhelming. The disparity between the brand's assertions and our tangible experience was undeniable. Although we acknowledge that individual responses to nootropics can vary, in the crowded marketplace of brain and memory supplements, several other formulations have delivered more pronounced effects in our trials [28-30].

Whilst Prevagen might offer some potential minor benefits to some individuals, our experience underscores the importance of tempered expectations. It's ultimately a very simple product missing many ingredients proven to support brain health, cognition and memory.

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Prevagen Pros and Cons

Pros:

  1. Contains Vitamin D: Essential for various physiological processes including bone health, immune function, and potentially cognitive function [31].
  2. Apoaequorin: An intriguing ingredient associated with cognitive health [32].
  3. Potential Mood Regulation: Due to the Vitamin D content, which has links to mood stabilization [33].

Cons:

  1. Questionable Efficacy: Limited noticeable effects on short-term memory and overall cognitive function based on some trials [34].
  2. Discrepancy with Claims: Real-world experience doesn't match the bold promises made by the brand [35].
  3. Lack of Peer-Reviewed Research: Academic circles challenge the product’s robustness in delivering its promises [36,37].
  4. Single Main Active Ingredient: Relies heavily on apoaequorin, without the inclusion of other well-researched nootropics.
  5. Legal Issues: Past concerns over marketing practices and claims made [38].
  6. Not a Complete Solution: May need to be supplemented with other products or strategies for full cognitive health.
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Prevagen Ingredients: A Scientific Overview

Prevagen Ingredients:

Vitamin D (50mcg), Apoaequorin (10mg)

1. Vitamin D (50mcg)

  • Evidence: A fat-soluble nutrient essential for bone health, immunity, and a myriad of physiological processes. Recent studies have explored its role in cognitive function. For instance, a meta-analysis demonstrated that individuals deficient in vitamin D exhibit impaired cognitive function [39]. Another study revealed vitamin D's potential role in protecting neurons and reducing inflammation [40].
  • Dosage in Prevagen vs. Studies: The Prevagen formula provides 50mcg of Vitamin D. While the recommended daily allowance for vitamin D varies, typical doses for cognitive health in studies have ranged from 10mcg to 125mcg [41]. Prevagen’s choice of Vitamin D falls within the range studied for cognitive health, which lends some credibility to its inclusion. The exact benefits, especially at the 50mcg dosage, still warrant more extensive research.

2. Apoaequorin (10mg)

  • Evidence: Originally discovered in jellyfish, apoaequorin piqued interest for its potential cognitive benefits. Preliminary studies, mainly sponsored by Quincy Bioscience, claim cognitive improvements in subgroups [42]. However, peer-reviewed, independent research on apoaequorin as a nootropic is scant. The existing studies are criticized for lacking robustness and transparency [43,44].
  • Dosage in Prevagen vs. Studies: Prevagen includes 10mg of apoaequorin. The trials sponsored by Quincy Bioscience have used dosages ranging from 5mg to 40mg [45]. However, without broad academic consensus, it’s challenging to ascertain an optimal dose. Apoaequorin remains controversial. The dearth of independent, peer-reviewed research makes it difficult to unequivocally endorse its efficacy. Prevagen’s claims, based largely on manufacturer-sponsored research, merit a cautious approach given the lack of wide scientific backing [46].

Prevagen Issues And Side Effects

Main Issues Experienced with Prevagen:

1. Limited Efficacy: The primary issue we encountered was the muted effect of Prevagen compared to other cognitive enhancers. Prevagen’s formula, despite its claims, did not show the same level of cognitive boost, particularly in the realm of short-term memory, as some of the leading nootropics we've reviewed [47].

2. Over-reliance on Apoaequorin: Much of Prevagen's marketing hinges on the inclusion of apoaequorin. However, the data supporting its effectiveness largely stems from studies sponsored by Quincy Bioscience, leading to skepticism around potential biases [48].

3. Vitamin D Dosage: While Vitamin D plays a role in cognitive health and overall well-being, the 50mcg dosage in Prevagen is closer to the upper daily limit for many individuals. This might be a cause for concern in individuals who obtain adequate Vitamin D from other sources [49].

Potential Side Effects:

1. Vitamin D: At higher doses, vitamin D can lead to hypercalcemia, a condition marked by elevated calcium levels in the blood. Symptoms include nausea, vomiting, weakness, and serious complications like bone pain and kidney problems [50]. While the 50mcg dosage in Prevagen is within the advised daily intake for many, combined with other sources, it could approach unsafe levels.

2. Apoaequorin: Given that apoaequorin is a relatively newer ingredient, its long-term effects are not fully known. Some reported side effects, albeit rare, include headache, dizziness, and heart palpitations [51].

3. Interaction with Other Medications: Like all supplements, there is always a risk of Prevagen interacting with medications. Those on medications, particularly for heart or kidney conditions, should be cautious and consult with a healthcare professional [52].

Our experience with Prevagen pointed to a noticeable gap between the product’s bold claims and its real-world effects. While it's not without some merit, potential users should be aware of the possible side effects, especially if combining with other sources of Vitamin D or if sensitive to new ingredients like apoaequorin.

Overall Results

Overall Results And Recommendation

Prevagen

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  • Disappointing Results: Prevagen's cognitive effects were subdued, with very little improvement experienced in memory and focus during our testing.
  • Missing Key Ingredients: Lacks many clinically-proven nootropic ingredients commonly found in top-tier brain and memory supplements.
  • Unconvincing Evidence: Most studies on apoaequorin originate from its manufacturers, raising validity concerns. Prevagen has also faced legal scrutiny for misleading advertising about its memory-enhancement claims, which were deemed unsubstantiated by regulators.
  • Cost vs. Efficacy: Given its price point, the tangible benefits delivered were disappointing.
  • Alternative Recommendation: NooCube outperformed Prevagen in our tests, delivering noticeable improvements to cognitive performance and memory. It's well-researched, scientifically backed, and our firsthand experience validated its efficacy claims.

NooCube

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Overall Verdict

After a thorough analysis and personal experience with Prevagen, the overarching sentiment we derive is one of mild disappointment. Prevagen’s claims, anchored on the unique inclusion of apoaequorin and a dosage of vitamin D, seem to promise significant cognitive enhancement, particularly in the domain of memory improvement [53]. However, the real-world effects felt notably subdued, especially when benchmarked against the industry's leading nootropics.

A central issue with Prevagen lies in its over-reliance on apoaequorin. While the ingredient might have some basis in science, the most vociferous claims surrounding its efficacy predominantly come from studies sponsored by Quincy Bioscience [54], the makers of Prevagen. This brings about a critical challenge: How do we reconcile these claims with an external, unbiased scientific validation?

Contrasting this with NooCube, our highest rated cognitive enhancer, the experience was like night and day. NooCube, with its robust ingredient profile including Bacopa Monnieri, Huperzine A, L-theanine, L-tyrosine, and Alpha GPC [55-59], offers a blend of time-tested and well-researched compounds known to facilitate improved cognition, heightened focus, and enhanced memory recall. Particularly, the synergy of these ingredients appears to deliver a heightened level of cognitive performance, making it a standout in the realm of nootropics and memory supplements.

In stark contrast to Prevagen, NooCube’s inclusion of adaptogens such as oat straw and antioxidants like resveratrol also provide additional neurological and overall health benefits [60,61], from neuroprotection to neurotransmitter enhancement.

Recommendation: Based on our experience and backed by scientific evidence, while Prevagen may offer some mild cognitive support, it falls short of its lofty claims. For those genuinely seeking an effective cognitive boost, we would recommend turning to supplements with a more potent and scientifically-backed ingredient profile, such as NooCube.

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