Prevagen Review: Does It Really Work? 

prevagen review memory supplement

9th July 2024

Prevagen Long-Term Testing And Results

Prevagen, a supplement from Quincy Bioscience, is often mentioned when discussing brain and memory aids. The product contains just two main ingredients: Vitamin D (50mcg) and Apoaequorin (10mg). The key question is, does it actually help? This review will look at the evidence supporting its effectiveness and explain the details of its ingredients and their amounts [1].

We've tested Prevagen ourselves over a 9-month period to provide a comprehensive assessment. It's worth mentioning that many people have shared negative feedback about both the product and its maker, Quincy Bioscience. We'll address these concerns as well [2]. We'll also discuss some alternative options for those considering other products.

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Overall Results And Recommendation

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  • Underwhelming Performance: Our evaluation found Prevagen’s impact on cognitive function to be minimal, with negligible improvements in memory and concentration observed during our testing period.
  • Lacks Essential Ingredients: The supplement is missing several well-researched nootropic ingredients that are typically present in leading brain and memory enhancers.
  • Questionable Research: A significant number of studies supporting apoaequorin, a key component of Prevagen, come directly from its manufacturers, casting doubt on their impartiality. Furthermore, Prevagen has faced legal challenges for misleading advertising, with regulatory bodies deeming their memory-enhancement claims unsubstantiated.
  • Cost vs. Benefit: Considering its price, the benefits provided by Prevagen were disappointing, making it difficult to justify the expense.
  • Our Recommendation: NooCube dramatically outperformed Prevagen in our tests, delivering noticeable improvements to cognitive performance and memory. It's well-researched, scientifically backed, and our firsthand experience validated its efficacy claims.

NooCube

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Quick Decision Guide - Quantumind vs Leading Nootropic (NooCube)

CRITERIA

Prevagen

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NooCube

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Overall Rating (From Our Experience Using Each Product)

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Main Benefits

Experimental and unproven novel ingredient claimed to support brain function and memory

Comprehensive cognitive improvement spanning brain health, cognitive performance and memory with a multi-ingredient blend

Scientific Backing

Limited and controversial

Strong, with many well-researched ingredients

Formula Complexity

Basic

Comprehensive

Brand Reputation Concerns

FTC legal ruling against Prevagen's manufacturer

Minimal to none

Cost

Premium

Premium

Commitment Time for Results

Months with variable results

Weeks, consistent use recommended

Servings Per Container

30

30

Capsules Per Container

30

90

User Feedback

Mixed, with many users citing minimal or no effects

Predominantly positive

Ingredients' Transparency

Mostly disclosed but with opaque proprietary ingredient (Apoaequorin)

Fully disclosed

Dosage Convenience

1 capsule daily

3 capsules daily

Potential Side Effects

Moderate risk

Low risk

Customer Support & Return Policy

Mixed reviews on customer service; return policy varies

Excellent, 60 day money-back guarantee

Product Availability

Widely available, some regional restrictions

Available through official site only

Additional Benefits

Some claims of improved sleep by some users

Boosts neurotransmitters, enhanced neuroprotection

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What Is Prevagen?

Prevagen is a dietary supplement that's relatively well-known in the brain supplement and nootropics market. The brand claims the product enhances brain health and cognitive function. The main promise of Prevagen is its ability to support brain function and boost memory.

The core ingredient in Prevagen is apoaequorin [3], a protein initially derived from a species of jellyfish. The company’s marketing claims this protein is safe and particularly effective in aiding brain function. They highlight a clinical study suggesting that apoaequorin can benefit individuals with normal cognitive abilities or mild cognitive impairment.

In addition to apoaequorin, Prevagen includes Vitamin D, a nutrient known for its wide range of health benefits, including a potential positive effect on cognitive health [4].

Despite its persuasive marketing, Prevagen's scientific basis has been questioned. Many experts are skeptical due to the limited peer-reviewed research backing the product's claims [5]. This skepticism is heightened by the company's history of legal and regulatory issues, particularly regarding their marketing and advertising practices [6].

Prevagen: Legal Issues

Prevagen came under the legal spotlight after the Federal Trade Commission (FTC) and New York State Attorney General challenged its makers, Quincy Bioscience, over their advertising practices. Specifically, the regulators contended that the company's cognitive health claims, particularly concerning memory enhancement, were unsubstantiated and misleading. Such regulatory actions raise concerns over the credibility of the brand and underscore the importance of evidence-based claims in the supplement industry. Notably, while many supplements make health-related claims, it's essential that these claims are backed by robust scientific research to ensure consumer safety and trust [7-10].

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Prevagen: A Critical Examination of Its Claims and Credibility

Prevagen positions itself as a solution to boost brain function and memory. A unique feature of Prevagen is its inclusion of apoaequorin [11], an ingredient the brand promotes as safe and uniquely suited for enhancing brain activity. Their cornerstone argument revolves around a clinical study suggesting apoaequorin's effectiveness among certain groups, notably those with standard cognitive function or minor impairments [12].

Prevagen dubs itself a 'breakthrough' for the brain and memory, citing improvements specifically in short-term memory capabilities3. One would expect such a supplement to be rooted in extensive, peer-reviewed research, given its bold assertions. However, a deeper dive into the scientific landscape reveals a notable absence of peer-reviewed validation for these claims [13].

Backing Prevagen's ambitious pursuits is Quincy Bioscience, headquartered in Madison, Wisconsin. The company outlines its mission as pioneering innovations centered on cognitive enhancements and tackling challenges such as age-related memory decline [14]. At face value, this sounds commendable. Yet, a look into their history unearths a slew of legal troubles and concerns regarding their marketing strategies [15], casting a shadow on their credibility.

Given this backdrop, it becomes essential for consumers to approach Prevagen's claims with an informed, discerning perspective. While the allure of enhanced cognitive function is tempting, relying solely on brand-propagated evidence, especially from a company with a checkered past, is a precarious position [16].

Prevagen's Claim: "Prevagen is an over-the-counter supplement for healthy brain function and memory improvement".
The Reality: While the nootropic market has many supplements that claim to boost brain function and memory, the efficacy of Prevagen hinges primarily on its unique ingredient, apoaequorin. Comprehensive research validating these broad claims, especially concerning long-term use and its effectiveness across diverse populations, remains scanty [17].

Prevagen's Claim: "Prevagen is formulated with apoaequorin which is safe and uniquely supports brain function as shown in a clinical study of subgroups of individuals who were cognitively normal or mildly impaired".
The Reality: Apoaequorin has indeed been highlighted in certain studies, but many of these lack peer review or are funded by parties with vested interests. Additionally, the specific clinical study cited has been critiqued for its methodology and transparency [18]. Safety is another concern; while initial studies suggest it's generally safe for consumption, more rigorous, independent, long-term studies are needed to confirm this [19].

Prevagen's Claim: "A breakthrough which helps your brain and helps memory. Shown to improve short-term memory".
The Reality: The term "breakthrough" implies a significant scientific discovery. As of now, the evidence supporting Prevagen's effect on short-term memory is not robust enough to warrant this label [20]. Preliminary findings do indicate potential benefits, but these are not universally accepted in the scientific community.

Prevagen's Claim: "Quincy Bioscience, makers of Prevagen, is focused on the discovery and development of novel technologies to support cognitive function and other normal health challenges such as mild memory loss associated with aging."
The Reality: While Quincy Bioscience's dedication to cognitive health is evident, it's worth noting that they have faced legal challenges concerning their marketing practices [21], which might raise eyebrows regarding their overall credibility.

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Does Prevagen Really Work?

Our Experience With Prevagen: A Reality Check

When we began our trial with Prevagen, we were intrigued by its bold claims of enhancing memory and supporting brain health. The excitement around apoaequorin [22] and its potential benefits for cognitive function drew our interest. Our aim was to conduct a thorough, unbiased evaluation.

In the early stages of our nine-month testing period, we watched for any noticeable improvements in cognitive abilities. Prevagen includes 50mcg of Vitamin D, known for its role in mood regulation and cognitive health [23]. Despite this, any effect on mood and mental clarity was minimal.

Apoaequorin, highlighted by Prevagen as its standout ingredient, is promoted as beneficial for brain function [24]. Although there were moments when we thought we perceived slight improvements in clarity, the overall impact was weak. Specifically, the promised short-term memory enhancements were not evident during our trial [25].

Our real-world experience contrasted sharply with Prevagen’s ambitious claims. The promised “breakthrough” in memory and cognitive function was not reflected in our observations. This sentiment is also shared by experts who question the product’s effectiveness based on limited peer-reviewed research [26, 27].

While Quincy Bioscience's goal of tackling cognitive challenges is admirable, our personal experience with their main product was disappointing. The gap between the company's claims and our tangible results was significant. Although individual responses to nootropics can differ, other brain and memory supplements we have tested produced more noticeable effects [28-30].

Prevagen might offer minor benefits to some users, but our experience suggests keeping expectations low. It’s ultimately a very basic product, lacking many ingredients that are scientifically proven to support brain health, cognition, and memory.

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Prevagen Pros and Cons

Pros:

  1. Contains Vitamin D: Essential for various physiological processes including bone health, immune function, and potentially cognitive function [31].
  2. Apoaequorin: An intriguing ingredient associated with cognitive health [32].
  3. Potential Mood Regulation: Due to the Vitamin D content, which has links to mood stabilization [33].

Cons:

  1. Questionable Efficacy: Limited noticeable effects on short-term memory and overall cognitive function based on some trials [34].
  2. Discrepancy with Claims: Real-world experience doesn't match the bold promises made by the brand [35].
  3. Lack of Peer-Reviewed Research: Academic circles challenge the product’s robustness in delivering its promises [36,37].
  4. Single Main Active Ingredient: Relies heavily on apoaequorin, without the inclusion of other well-researched nootropics.
  5. Legal Issues: Past concerns over marketing practices and claims made [38].
  6. Not a Complete Solution: May need to be supplemented with other products or strategies for full cognitive health.
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Prevagen Ingredients: A Scientific Overview

Prevagen Ingredients:

Vitamin D (50mcg), Apoaequorin (10mg)

1. Vitamin D (50mcg)

  • Evidence: A fat-soluble nutrient essential for bone health, immunity, and a myriad of physiological processes. Recent studies have explored its role in cognitive function. For instance, a meta-analysis demonstrated that individuals deficient in vitamin D exhibit impaired cognitive function [39]. Another study revealed vitamin D's potential role in protecting neurons and reducing inflammation [40].
  • Dosage in Prevagen vs. Studies: The Prevagen formula provides 50mcg of Vitamin D. While the recommended daily allowance for vitamin D varies, typical doses for cognitive health in studies have ranged from 10mcg to 125mcg [41]. Prevagen’s choice of Vitamin D falls within the range studied for cognitive health, which lends some credibility to its inclusion. The exact benefits, especially at the 50mcg dosage, still warrant more extensive research.

2. Apoaequorin (10mg)

  • Evidence: Originally discovered in jellyfish, apoaequorin piqued interest for its potential cognitive benefits. Preliminary studies, mainly sponsored by Quincy Bioscience, claim cognitive improvements in subgroups [42]. However, peer-reviewed, independent research on apoaequorin as a nootropic is scant. The existing studies are criticized for lacking robustness and transparency [43,44].
  • Dosage in Prevagen vs. Studies: Prevagen includes 10mg of apoaequorin. The trials sponsored by Quincy Bioscience have used dosages ranging from 5mg to 40mg [45]. However, without broad academic consensus, it’s challenging to ascertain an optimal dose. Apoaequorin remains controversial. The dearth of independent, peer-reviewed research makes it difficult to unequivocally endorse its efficacy. Prevagen’s claims, based largely on manufacturer-sponsored research, merit a cautious approach given the lack of wide scientific backing [46].

Prevagen Issues And Side Effects

Main Issues Experienced with Prevagen:

1. Limited Efficacy: The primary issue we encountered was the muted effect of Prevagen compared to other cognitive enhancers. Prevagen’s formula, despite its claims, did not show the same level of cognitive boost, particularly in the realm of short-term memory, as some of the leading nootropics we've reviewed [47].

2. Over-reliance on Apoaequorin: Much of Prevagen's marketing hinges on the inclusion of apoaequorin. However, the data supporting its effectiveness largely stems from studies sponsored by Quincy Bioscience, leading to skepticism around potential biases [48].

3. Vitamin D Dosage: While Vitamin D plays a role in cognitive health and overall well-being, the 50mcg dosage in Prevagen is closer to the upper daily limit for many individuals. This might be a cause for concern in individuals who obtain adequate Vitamin D from other sources [49].

Potential Side Effects:

1. Vitamin D: At higher doses, vitamin D can lead to hypercalcemia, a condition marked by elevated calcium levels in the blood. Symptoms include nausea, vomiting, weakness, and serious complications like bone pain and kidney problems [50]. While the 50mcg dosage in Prevagen is within the advised daily intake for many, combined with other sources, it could approach unsafe levels.

2. Apoaequorin: Given that apoaequorin is a relatively newer ingredient, its long-term effects are not fully known. Some reported side effects, albeit rare, include headache, dizziness, and heart palpitations [51].

3. Interaction with Other Medications: Like all supplements, there is always a risk of Prevagen interacting with medications. Those on medications, particularly for heart or kidney conditions, should be cautious and consult with a healthcare professional [52].

Our experience with Prevagen pointed to a noticeable gap between the product’s bold claims and its real-world effects. While it's not without some merit, potential users should be aware of the possible side effects, especially if combining with other sources of Vitamin D or if sensitive to new ingredients like apoaequorin.

Overall Results

Overall Results And Recommendation

Prevagen

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Overall Rating

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  • Underwhelming Performance: Our evaluation found Prevagen’s impact on cognitive function to be minimal, with negligible improvements in memory and concentration observed during our testing period.
  • Lacks Essential Ingredients: The supplement is missing several well-researched nootropic ingredients that are typically present in leading brain and memory enhancers.
  • Questionable Research: A significant number of studies supporting apoaequorin, a key component of Prevagen, come directly from its manufacturers, casting doubt on their impartiality. Furthermore, Prevagen has faced legal challenges for misleading advertising, with regulatory bodies deeming their memory-enhancement claims unsubstantiated.
  • Cost vs. Benefit: Considering its price, the benefits provided by Prevagen were disappointing, making it difficult to justify the expense.
  • Our Recommendation: NooCube dramatically outperformed Prevagen in our tests, delivering noticeable improvements to cognitive performance and memory. It's well-researched, scientifically backed, and our firsthand experience validated its efficacy claims.

NooCube

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Overall Verdict

After thoroughly analyzing and using Prevagen for nine months, our overall impression is one of mild disappointment. Prevagen promises significant cognitive enhancement, particularly memory improvement, due to its inclusion of apoaequorin and a dose of Vitamin D [53]. However, the actual effects observed were quite minimal, especially compared to top nootropic supplements.

One major issue with Prevagen is its heavy reliance on apoaequorin. While there may be some scientific basis for this ingredient, most of the claims about its effectiveness come from studies sponsored by Quincy Bioscience, the company behind Prevagen [54]. This raises concerns about the validity of these claims without independent scientific validation.

In comparison, NooCube, our top-rated cognitive enhancer, provided a stark contrast in performance. NooCube's comprehensive ingredient list includes Bacopa Monnieri, L-theanine, L-tyrosine and Alpha GPC, all of which are well-researched and known to enhance cognitive function, focus, and memory [55-59]. The combination of these ingredients appears to deliver a much more noticeable improvement in cognitive performance, setting it apart in the nootropic market.

Unlike Prevagen, NooCube also includes adaptogens like oat straw and antioxidants such as resveratrol, offering additional benefits for neurological health and overall well-being [60,61]. These ingredients provide neuroprotection and enhance neurotransmitter function, contributing to its superior efficacy.

Our Recommendation: Based on our experience and supported by scientific evidence, Prevagen offers only mild cognitive support and falls short of its bold claims. For those seeking a significant cognitive boost, we recommend considering brain supplements with a more potent and scientifically-backed ingredient profile, such as NooCube.

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